Research Project 1
| Title | Synthesis, Characterization and Biological Activity of Some New Heterocyclic Compounds Based on U. V. Absorbing Materials using Mannich Reaction. |
| Agency | UGC New Delhi |
| Period | 2012-2015 |
| Grant/Amount Mobilized (Indian Rupees) |
3,19000/- |
Highlights:
We concluded these task with a solvent-free, environmentally clean and simple one-pot multi-component reaction etiquette for the developed of well-organized synthesis of γ-methylamino-β-hydroxycarbonyl scaffolds with excellent yields via one-pot three-component reaction of heterocyclic aldehyde, phenol as ultraviolet absorbing materials and various amide derivatives/primary/secondary amines with using EAN as reusable ionic liquid as catalyst under ambient temperature.
These compounds were screened for their in vitro antifungal-, antibacterial- and anti-tuberculosis activity and we found that, some compounds shows good activity. The Molecular docking studies for selected compounds including their energy profile was observed quite relevant to the selected bioavailability based on structural properties.
Research Project 2
| Title | An efficient synthesis of biologically active compounds via one-step synthesis from diverse heterocyclic scaffolds |
| Agency | DST-SERB, New Delhi |
| Period | 2016-2021 |
| Grant/Amount Mobilized (Indian Rupees) |
48,62000/- |
Highlights:
We try to explore the sustainable route for the development of Bioactive-Heteocyclic compounds likewise: enlargement of the Pyridine, Pyrimidine, Pyrimidone, substituted Dihydropyridopyrazole, Spiro-Heterocyclic derivatives and Pyrano-Pyrazoles scaffolds using Ionic liquids, deep-eutectic solvents including GAP chemistry for MCR’s protocol.
Based on the QSAR Study, We validate the variations in the skeleton which leads to the formation of novel active molecules having probably lower toxicity and targeting good bioavailability including anticancer and NNRT’s Inhibitory activity etc.
Research Project 3
| Title | Chemiresistive VOC Sensor in Pilot Scale Absorber System for Laboratory VOC Recycling |
| Agency |
Royal Society of Chemistry (Ongoing) |
| Period | 2024-25 |
| Grant/Amount Mobilized (Indian Rupees) |
Ongoing Principal Investigator 1030419/- (10000 £) |
