Publications

(57) Alkoxy-functionalised dihydropyrimido [4, 5-b] quinolinones enabling anti-proliferative and anti-invasive agents

Subham G Patel, Ira Sharma, Mehul P Parmar, Joaquina Nogales, Chirag D Patel, Savan S Bhalodiya, Disha P Vala, Niraj V Shah, Sourav Banerjee, Hitendra M Patel, Chemical Communications, 2024

https://doi.org/10.1039/D4CC01219D

 

(56) Phytochemical Analysis and Biological Application of 𝐴𝑏𝑟𝑢𝑠 𝑃𝑟𝑒𝑐𝑎𝑡𝑜𝑟𝑖𝑢𝑠 Linn: A Comprehensive Review, Journal of Chemical Reviews, 2024, 6(3), 353-378.

Dhruv M.Barot, Mehul P. Parmar and Hitendra M. Patel

 https://doi.org/10.48309/jcr.2024.457518.1330

 

(55) Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1, 2, 3-triazole-4-yl) propoxy) benzaldehydes: In Vitro Antimicrobial, Antimalarial Activities and In silico Docking Study

Mohammed A Al-Salehi, Mehul P Parmar, Dhanji P Rajani, Hitendra M Patel, Jignesh H Trivedi, Journal of Molecular Structure, 2024, 1317. 139006.

https://doi.org/10.1016/j.molstruc.2024.139006

 

(54) Click-chemistry mediated synthesis of OTBN-1,2,3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities

Disha P Vala, Amy Dunne Miller, Aditi Atmasidha, Mehul P Parmar, Chirag D Patel, Dipti B Upadhyay, Savan S Bhalodiya, Aday González-Bakker, Adam N Khan, Joaquina Nogales, José M Padrón, Sourav Banerjee, Hitendra M Patel, Bioorganic Chemistry, 2024, 149, 107485.

https://doi.org/10.1016/j.bioorg.2024.107485
 

(53) “A TETRAHYDOPYRIMIDINECARBOXAMIDE DERIVATIVES”

Dipti B. Upadhyay, Ruturajsinh M. Vala, Joaquina Nogales, Sourav Banerjee, and, Hitendra M. Patel, 2024/3/18, IN Patent, 528662

 

(52) A green bio-organic catalyst (taurine) promoted one-pot synthesis of (R/S)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches

Mehul P Parmar, Disha P Vala, Savan S Bhalodiya, Dipti B Upadhyay, Chirag D Patel, Subham G Patel, Srinivasa R Gandholi, Althaf H Shaik, Amy Dunne Miller, Joaquina Nogales, Sourav Banerjee, José M Padrón, Nasser Amri, Nagesh Kumar Kandukuri, Hitendra M Patel, RSC Advances, 2024, 14(13), 9300-9313.

10.1039/D4RA01391C

 

(51) In Silico Exploration Of Acetic Acid Driven Multicomponent Synthesis: Design, Characterization, And Antioxidant Evaluation Of Spiroacridines And Spiroquinolines

Subham G Patel, Dipti B Upadhyay, Nirajkumar V Shah, Mehul P Parmar, Paras J Patel, Apoorva Malik, Rakesh K Sharma, Hitendra M Patel, RSC Sustainability, 2024, 2(4),1128-1141

https://doi.org/10.1039/D4SU00024B

 
(50) Indole clubbed 2, 4‐thiazolidinedione linked 1, 2, 3‐triazole as a potent antimalarial and antibacterial agent against drug‐resistant strain and molecular modeling studies
Dipti B Upadhyay, Jaydeep A Mokariya, Paras J Patel, Subham G Patel, Anwesha Das, Arijit Nandi, Joaquina Nogales, Nachiket More, Amit Kumar, Dhanji P Rajani, Mahesh Narayan, Jyotish Kumar, Sourav Banerjee, Suban K Sahoo, Hitendra M Patel, 2024, Archiv der Pharmazie, e2300673.
https://doi.org/10.1002/ardp.202300673
 
(49) Therapeutic Delivery Potential of Covalent Organic Framework (COF): Intuition from Theoretical Calculations,
Mohsen D Mohammadi, Hitler Louis, Innocent Benjamin, Daniel Oche, Hitendra M Patel, Henry O Edet, ChemistrySelect, 2024, 9(3), e202303529.
https://doi.org/10.1002/slct.202303529
 
(48) Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4 (2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study.
Savan S Bhalodiya, Mehul P Parmar, Dipti B Upadhyay, Chirag D Patel, Disha P Vala, Dhanji Rajani, Hitendra M Patel,
Results in Chemistry, 2024, (7) , 101304.

https://doi.org/10.1016/j.rechem.2023.101304
 
(47) Deep eutectic mixture (DEM)-assisted multicomponent synthesis of heterocycles,
D.M. Patel, H.M. Patel
Multicomponent Synthesis: Bioactive Heterocycles,Book Chapter, De Gruyter, 2023, Volume 5, page np.399-409

https://doi.org/10.1515/9783110985313
 
(46) An efficient, catalyst-free and aqueous ethanol-mediated synthesis of 5-((2-aminothiazol-5-yl)(phenyl)methyl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives and their antioxidant activity.
Paras J. Patel, Subham G. Patel, Dipti B. Upadhyay, Logeswari Ravi, Anuradha Dhanasekaran and Hitendra M. Patel
RSC Advances, 35, 2023

DOI https://doi.org/10.1039/D3RA03998F
 
(45) Insights into microwave assisted synthesis of spiro-chromeno[2,3-d]pyrimidines using PEG-OSO3H catalyst: DFT study and their antiproliferative activity,
Subham G. Patel; Paras J. Patel; Dipti B. Upadhyay; Adrián Puerta; Apoorva Malik; Nagesh K. Kandukuri; Rakesh K Sharma; José M. Padrón; Hitendra M. Patel
Journal of Molecular Structure, 2023,
DOI: 10.1016/j.molstruc.2023.136174
 
(44) Recent developments in the Hantzsch synthesis of dihydropyridines,
R.M. Vala, H.M. Patel,
Advances in Heterocyclic Chemistry (Book Chapter Series), 2023, Elsevier, Volume,141.
 
(43) Polysaccharide-based nanogels for biomedical applications: A comprehensive review,
Fouad Damiri, Satish Rojekar, Yahya Bachra, Rajender S Varma, Swetha Andra, Satheeshkumar Balu, Chandrakantsing Vijaysing Pardeshi, Paras J Patel, Hitendra M Patel, Ana Cláudia Paiva-Santos, Mohammed Berrada, Mónica C García
Journal of Drug Delivery Science and Technology, 2023, 84, 104447,
DOI: 10.1016/j.jddst.2023.104447
 
(42) Catalyst-free synthesis of imidazo[5,1-b]quinazolines and their antimicrobial activity
Paras J. Patel; Ruturajsinh M. Vala; Subham G. Patel; Dipti B. Upadhyay; Dhanji P. Rajani; Fouad Damiri; Mohammed Berrada; Hitendra M. Patel,
Journal of Molecular Structure, 2023, 1285, 135467,
DOI: 10.1016/j.molstruc.2023.135467
 
(41) Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)
Mehul P. Parmar, Ruturajsinh M. Vala, and Hitendra M. Patel*
ACS Omega 2023, 8(2), 1759−1816
DOI: 10.1021/acsomega.2c05349
 
(40) Catalyst-Free, Room-Temperature Accessible Regioselective Synthesis of Spiroquinolines and Their Antioxidant Study
Paras J. Patel; Divyang M. Patel; Ruturajsinh M. Vala; Subham G. Patel; Dipti B. Upadhyay; Yuvaraj Pannerselvam; Hitendra M. Patel*,
ACS Omega, 2023, 8(1), 444−456
DOI: 10.1021/acsomega.2c05020
 
(39) Catalytic Stereoselective Multicomponent Reactions for the Synthesis of Spiro Derivatives: Recent Progress
DM Patel, PJ Patel, HM Patel
European Journal of Organic Chemistry
https://doi.org/10.1002/ejoc.202201119
 
(38) Microwave-assisted multicomponent synthesis of antiproliferative 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones
Subham G. Patel; Aday González-Bakker; Ruturajsinh M. Vala; Paras J. Patel; Adrián Puerta; Apoorva Malik; Rakesh K. Sharma; José M. Padrón; Hitendra M. Patel

RSC advances (2022) 12 (47), 30404-30415
 
(37) Water mediated TBAB catalyzed synthesis of spiro-indoline-pyrano[3,2-c]quinolines as α-amylase inhibitor and in silico studies
Dipti B. Upadhyay, Ruturajsinh M. Vala, Subham G. Patel, Paras J.Patel, CelestineChi, Hitendra M. Patel

Journal of Molecular Structure (2023) 1273, 134305
 
(36) Versatile Synthetic Platform for 1,2,3-Triazole Chemistry
Disha P. Vala; Ruturajsinh M. Vala; Hitendra M. Patel

ACS Omega (2022) 7,42, 36945–36987
 
35-Annals-of-Medicine (35) Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity
Ruturajsinh M. Vala; Vasudha Tandon; Lynden G. Nicely; Luxia Guo; Yanlong Gu; Sourav Banerjee; Hitendra M. Patel

Annals of Medicine 54 (1), 2549-2561
 
34-Phosp (34) Crystal structure, antibacterial and antifungal evaluation of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1H)-(thi)ones
Mayank G. Sharma; Ruturajsinh M. Vala; Dhanji P. Rajani; Venkatachalam Ramkumar; Ramesh L. Gardas; Sourav Banerjee; Hitendra M. Patel

Phosphorus, Sulfur, and Silicon and the Related Elements (2022) 1-9
  34 Phosphoru
RSC-Advances (33) One-pot two-step catalytic synthesis of 6-amino-2-pyridone-3,5-dicarbonitriles enabling anti-cancer bioactivity
Lynden G. Nicely; Ruturajsinh M. Vala; Dipti B. Upadhyay; Joaquina Nogales; Celestine Chi; Sourav Banerjee; Hitendra M. Patel

RSC Adv.,( 2022) 37 12, 23889-23897
  33-RSC-Advances
(32) Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones
Subham G. Patel, Ruturajsinh M. Vala, Paras J. Patel, Dipti B. Upadhyay, V. Ramkumarb, Ramesh L. Gardas and Hitendra M. Patel
RSC Adv., (2022) 12, 18806-1882
0 (IF=4.036)
 
Bioscience Report Page (31) Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo.
Vasudha Tandon; Ruturajsinh M.Vala; Albert Chen; Robert L. Sah; Hitendra M. Patel; Michael C. Pirrung; Sourav Banerjee
Biosci Rep (2022) 42(2): BSR20212721 (I.F. = 3.84)
  31 Bioscience  Graphical Imag
(30) Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones
Ruturajsinh M. Vala, Mayank G. Sharma, Divyang M. Patel, Adrián Puerta, José M. Padrón, Venkatachalam Ramkumar, Ramesh L. Gardas, Hitendra M. Patel
Arch Pharm. 2021, 354:e2000466 (I.F. = 2.590).
 
(29) Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-b]quinolinones.
Mayank G. Sharma,Ruturajsinh M. Vala and Hitendra M. Patel
RSC Advances. 2020, 10, 35499-35504. (I.F. = 3.119).
 
(28) A novel substrate directed multicomponent reaction for the synthesis of tetrahydro-spiro[pyrazolo[4,3-f]quinoline-8,5′-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolines via selective multiple C-C bonds formation under metal-free reaction condition.
Divyang M. Patel, Hetal J. Patel, José M. Padrón, and Hitendra M. Patel,
RSC Advances. 2020, 10, 19600-19609. (I.F. = 3.119).
 
   
(27) One-Pot Assembly for Synthesis of 1,4-Dihydropyridine Scaffold and Their Biological Applications.,
Mayank G. Sharma, JuheePandya, Divyang M. Patel, Ruturajsinh M. Vala,V. Ramkumar, Raghunandankumar Subramanian,Vivek K. Gupta, Ramesh L. Gardas, AnuradhaDhanasekaran & Hitendra M. Patel,
Polycyclic Aromatic Compounds, 2019, 39 (5), 395-485. (I.F. = 1.894).
 
   
(26) Trimethylglycine-Betaine-Based-Catalyst-Promoted Novel and Ecocompatible Pseudo-Four-Component Reaction for Regioselective Synthesis of Functionalized 6, 8-Dihydro-1′ H, 5 H-spiro [[1, 3] dioxolo [4, 5-g] quinoline-7, 5′-pyrimidine]-2′, 4′, 6′(3′ H)-trione Derivatives
DM Patel, HM Patel,
ACS Sustainable Chemistry & Engineering, 2019, 7(22), P.P.18667−18676. (I.F. = 7.632).
 
   
(25) Impact of an aryl bulky group on a one-pot reaction of aldehyde with malononitrile and N-substituted 2-cyanoacetamide.
Ruturajsinh M. Vala, Divyang M. Patel, Mayank G. Sharma and Hitendra M. Patel,
RSC Advances, 2019,9, 28886-28893. (I.F. = 3.119)
 
   
(24) Hydroxyl Alkyl Ammonium Ionic liquid assisted Green and One-potregioselective access to Functionalized Pyrazolodihydropyridine core and theirpharmacological evaluation.
Divyang M Patel, Mayank G Sharma, Ruturajsinh M Vala, Irene Lagunes, AdriánPuerta, José M Padrón, Dhanji P Rajani, Hitendra M Patel,
Bioorganic chemistry, 2019,86, 137-150. (I.F. = 4.831)
 
   
(23) A Practical Green Visit to the Functionalized [1,2,4]Triazolo[5,1- b ] quinazolin-8(4 H )one Scaffolds Using the Group-Assisted Purification (GAP) Chemistry and Their Pharmacological Testing.
D. M. Patel, R.M. Vala, M. G. Sharma, D. P. Rajani, H. M. Patel,
ChemistrySelect, 2019, 4(3) ,1031-1041. (I.F. = 1.811)
 
   
(22) Anti-Proliferative 1,4-Dihydropyridine and Pyridine Derivatives Synthesized through a Catalyst-Free, One-Pot Multi-Component Reaction.
Mayank G. Sharma, Ruturajsinh M. Vala, Divyang M. Patel, Irene Lagunes, Miguel X. Fernandes, Dr. José M. Padrón, Venkatachalam Ramkumar, Dr. Ramesh L. Gardas, Prof. Hitendra M. Patel,
ChemistrySelect. 2018, 3(43), 12163–12168. (I.F. = I.F. = 1.811)
 
   
(21) Synthesis, molecular docking and biological evaluation of Mannich products based on thiophene nucleus using ionic liquid.
Hitendra M. Patel, Dhanji P. Rajani, Mayank G. Sharma, Hardik G Bhatt.
Letters in Drug Design & Discovery, 2019, 16(2). (I.F. = 1.169)
 
   
(20) Synthesis, Characterizations and Microbial Studies of Novel Mannich Products Using Multicomponent Reactions.,
Hitendra M. Patel,
Current Bioactive Compounds. 278-2018, 14(3), 288. (I.F. = 0.69)
 
   
(19) Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridinederivatives based on thiophene moiety via multicomponent reaction.
Sharma M.G, Rajani D.P., Patel H.M.,
Royal Society Open Science, 2017,4 (6). (I.F. = 2.68)
 
   
(18) Facile synthesis and biological evaluation of new Mannich products as potential antibacterial, antifungal and antituberculosis agents: Molecular docking study.,
Hitendra M. Patel, Kinjal D. Patel, Hitesh D. Patel,
Current Bioactive Compounds, 2017,13(1). (I.F. = 0.69)
 
   
(17) Synthesis of New Mannich Products Bearing Quinoline Nucleous Using Reusable Ionic Liquid and Antitubercular Evaluation.,
Hitendra M. Patel,
Green and Sustainable Chemistry, 2015, 5, 137-144,. (G.I.F. = 3.08)
 
   
  (16) Solvent-free synthesis of mannich products catalyzed by ethyl ammonium Nitrate as reusable ionic liquid and there in vitro microbial studies., Hitendra M. Patel, International Journal of Recent Scientific Research, 2014, 5(10), 1799-1805.

(15) Design, synthesis and biological evaluation of new Mannich products using ethyl ammonium nitrate as reusable ionic liquid., Hitendra M. Patel,IOSR Journal of Applied Chemistry, 2014, 7(8), Ver. II., 40-47,.

(14) Synthesis, Characterization and Dyeing Assessment of Novel Bisazo-Acid Dyes Derived from2-hydroxy-4-Methoxy benzophenone-5-sulphonic acid.,Hitendra M. Patel,International Journal of Scientific & Engineering Research. , 2014, 5(1), 2213-2217.

(13) Synthesis, structure investigation and dyeing assessment of novel bisazo disperse dyes derived from u v absorbing material. Hitendra M. Patel. IOSR Journal of Applied Chemistry. 2014, 6(5), 51-55.

(12) Synthesis, characterization and application of some novel mordent and heterocyclic disperse dyes based on polyester and wool fibers., Hitendra M. Patel, Orbital – The Electronic Journal of Chemistry. 2012, 4(3), 159-170.

(11) Synthesis, characterization and dyeing behaviour of heterocyclic acid dyes and mordent acid dyes on wool and silk fabrics., Hitendra M. Patel.,J. Serb. Chem. Soc. 2012, 77(11), 1551-1560. (I.F. =1.097)

(10) Material applications of novel heterocyclic disperse and mordent dyes based on 2-Butyl-3-(4-hydroxybenzoyl)benzofuran, Hitendra M. Patel, Journal of Advances in Applied Science Research. 2012, 3(1), 235-241,.

(9) The synthesis, antimicrobial activity and absorption studies of some novel heterocyclic dyes based on 4-hexylbenzene-1,3-diol., Hitendra M. Patel, European journal of Chemistry, 2012, 3(1), 44-50,. (I.F.=0.4531)

(8) Dyeing Assessment of Some Novel Mordent and Heterocyclic Disperse Dyes based on Dihydrobenzofuran Derivatives on to Polyester and Wool Fibers., Hitendra M. Patel, Der ChemicaSinica. 2012, 3(1),175- 181,.

(7) Synthesis, Characterization and Application of Some Novel Mordent and Heterocyclic Disperse Dyes based on 2-Butyl-3-(4-hydroxybenzoyl) benzofuran., Hitendra M. Patel, Der ChemicaSinica. 2011, 2(6), 89-96.

(6) Synthesis, characterization and dyeing assessment of novel acid azo dyes and mordent acid azo dyes based on 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid on wool and silk fabrics, Hitendra M. Patel, Bharat C. Dixit, Journal of Saudi Chemical Society. 2014, 18(5), 507-512. (I.F. =3.517)

(5) Synthesis, Characterization and Printing Application of Solvent Dyes Based on 2-Hydroxy-4-n-octyloxybenzophenone., Hitendra M. Patel, Bharat C. Dixit, E-Journal of Chemistry. 2011, 8(2), 615-620. (I.F. =1.727)

(4) Material Applications of Novel Disperse and Mordent Azo Dyes based on 2-Hydroxy-4-Methoxy benzophenone., Hitendra M. Patel, Bharat C. Dixit, Asian Journal of Chemistry. 2010, 22(2), 921-928.

(3) Synthesis, characterization and dyeing assessment of novel acid azo dyes and mordent acid azo dyes based on 2-hydroxy-4-methoxybenzophenone on wool and silk fabrics.,Hitendra M. Patel, Bharat C. Dixit, Ritu B. Dixit and Dhirubhai J. Desai, Journal of Serb. Chem. Soc. 2010, 75(5), 605-614 . (I.F. = 1.097)

(2) Studies on dyeing performance of novel acid azo dyes and mordent acid azo dyes based on 2,4-dihydroxybenzophenone., Hitendra M. Patel, Bharat C. Dixit, Dhirubhai J. Desai and Ritu B. Dixit, E-journal of chemistry. 2009, 6(2), 315-322. (I.F. =1.727)

(1) Synthesis and application of new mordent and disperse azo dyes based on 2, 4-dihydroxybenzophenone., Hitendra M. Patel, Bharat C. Dixit and Dhirubhai J. Desai, Journal of Serb. Chem. Soc. 2007, 72, 119-127. (I.F. = 1.097)

Published Books

Sr. No. Title of the Book Publisher
1 Synthetic Dyes and Their Applications (Part – 1) LAP LAMBERT Academic Publishing
GmbH & Co.,Germany
ISBN:978-3-8473-4584-8
2 Synthetic Dyes and Their Applications (Part – 2) LAP LAMBERT Academic Publishing
GmbH & Co.,Germany
ISBN:978-3-8484-3761-0
3 Study Guide To Chemistry For (First year B. Sc.) LAP LAMBERT Academic Publishing
GmbH & Co.,Germany
ISBN: 978-3-659-26367-5