Publication

64 Antimicrobial Efficacy of 1, 2, 3-Triazole-Incorporated Indole-Pyrazolone against Drug-Resistant ESKAPE Pathogens: Design and Synthesis, Dipti B Upadhyay, Jaydeep A Mokariya, Paras J Patel, Subham G Patel, Mehul P Parmar, Disha P Vala, Febe Ferro, Dhanji P Rajani, Mahesh Narayan, Jyotish Kumar, Sourav Banerjee, Hitendra M Patel, ACS Bio & Med Chem Au, 2025, 5(1), 66–77.

DOI: 10.1021/acsbiomedchemau.4c00060

 

63 Target isolation and anti-proliferative potency of furocoumarin derivative from Aegle marmelos fruit pulp, Dhruv M. Barot, Dipti B. Upadhyay, Disha P. Vala, Mehul P. Parmar, Aday González-Bakker, Adam N. Khan, José M. Padrón & Hitendra M. Patel, Natural Product Research, 2025, DOI: 10.1080/14786419.2025.2477214

 

62 QSAR, Antimicrobial, and Antiproliferative Study of (R/S)-2-Thioxo-3,4-dihydropyrimidine-5-carboxanilides, Mehul P. Parmar, Anwesha Das, Disha P. Vala, Savan S. Bhalodiya, Chirag D. Patel, Shana Balachandran, Nagesh Kumar Kandukuri, Shreya Kashyap, Adam N. Khan, Aday González-Bakker, Madan Kumar Arumugam, José M. Padrón, Arijit Nandi, Sourav Banerjee*, Hitendra M. Patel*, ACS Omega, 2025,10(7), 7013–7026. DOI: 10.1021/acsomega.4c09899

 

 

61 Alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones enabling anti-proliferative and anti-invasive agents, Subham G. Patel; Ira Sharma; Mehul P. Parmar; Joaquina Nogales; Chirag D. Patel;   Chemical Communications, 2024, 60(55), 7093-7096.  DOI: 10.1039/D4CC01219D

60 Click-chemistry mediated synthesis of OTBN-1, 2, 3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities, Disha P Vala, Amy Dunne Miller, Aditi Atmasidha, Mehul P Parmar, Chirag D Patel, Dipti B Upadhyay, Savan S Bhalodiya, Aday González-Bakker, Adam N Khan, Joaquina Nogales, José M Padrón, Sourav Banerjee, Hitendra M Patel, Bioorganic chemistry,2024, 107485.

DOI: 10.1016/J.BIOORG.2024.107485

59 Acetic acid‐driven one‐pot synthesis of 4, 7‐dihydro‐[1, 2, 3] thiadiazolo [5, 4‐b] pyridine‐6‐carboxamides and Pharmacological Evaluations, Savan S Bhalodiya, Mehul P Parmar, Chirag D Patel, Subham G Patel, Disha P Vala, Nandhakumar Suresh, Bhuvaneshwari Jayachandran, Madankumar Arumugam, Mahesh Narayan, Hitendra M Patel, ChemMedChem,2024,  e202400595.

DOI: 10.1002/cmdc.202400595

 

58 In Silico Molecular Docking and In Vitro Antimicrobial Evaluation of Novel 2-(4-(3-(4-formylphenoxy)propyl)-1H-1,2,3-triazol-1-yl)-N-Phenylacetamides, Mohammed A Al-Salehi, Jignesh Harikrishna Trivedi, Dhanji P Rajani, Hitendra M Patel, Asian Journal of Organic Chemistry,2024,  e202400489. DOI: 10.1002/AJOC.202400489

57 Novel benzylidene derivatives: Synthesis and their antimicrobial and anticancer studies and in silico investigations, Sarkar MA Kawsar, Md Ahad Hossain, Mohammad I Hosen, Mehul P Parmar, Subham G Patel, Hitendra M Patel, Imtiaj Hasan, Suvro Biswas, Md Abu Saleh, Chemical Physics Impact, 2024, 100786. DOI: 10.1016/J.CHPHI.2024.100786

56 Phytochemical Analysis and Biological Application of 𝐴𝑏𝑟𝑢𝑠 𝑃𝑟𝑒𝑐𝑎𝑡𝑜𝑟𝑖𝑢𝑠 Linn: A Comprehensive Review, Dhruv M Barot, Mehul P Parmar, Hitendra M Patel, Journal of Chemical Reviews, 2024, 6(3), 353-378. DOI: 10.48309/jcr.2024.457518.1330

 

55 One-pot synthesis of tetrahydropyrimidinecarboxamides enabling in vitro anticancer activity: a combinative study with clinically relevant brain-penetrant drugs, Dipti B Upadhyay, Joaquina Nogales, Jaydeep A Mokariya, Ruturajsinh M Vala, Vasudha Tandon, Sourav Banerjee, Hitendra M Patel, RSC Advances, 2024, 14(37), 27174-27186. DOI: 10.1039/D4RA04171B

 

54 Chapter 10, Microneedle of Drug Delivery Systems: Nanoscience and Nanotechnology for Smart Prevention, Diagnostics and Therapeutics: Fundamentals to Applications, Fouad Damiri, Hitendra M. Patel, Sagar Salave, K. Bharathi, Nagavendra Kommineni, B.H. Jaswanth Gowda, Karthika Paul, Sanju Bala Dhull, Mohammed Berrada, 2024. DOI: 10.1002/9781394175222.CH10

53 Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1,2,3-triazole-4-yl)propoxy)benzaldehydes: In vitro antimicrobial, antimalarial activities and In silico docking study, Mohammed A Al-Salehi, Mehul P Parmar, Dhanji P Rajani, Hitendra M Patel, Jignesh H Trivedi, Journal of Molecular Structure, 2024, 139006. DOI: 10.1016/J.MOLSTRUC.2024.139006

52 Indole clubbed 2, 4‐thiazolidinedione linked 1, 2, 3‐triazole as a potent antimalarial and antibacterial agent against drug‐resistant strain and molecular modeling studies, Dipti B Upadhyay, Jaydeep A Mokariya, Paras J Patel, Subham G Patel, Anwesha Das, Arijit Nandi, Joaquina Nogales, Nachiket More, Amit Kumar, Dhanji P Rajani, Mahesh Narayan, Jyotish Kumar, Sourav Banerjee, Suban K Sahoo, Hitendra M Patel, Archiv der Pharmazie, 2024, e2300673.  DOI: 10.1002/ARDP.202300673

51 In silico exploration of acetic acid driven multicomponent synthesis: design, characterization, and antioxidant evaluation of spiroacridines and spiroquinolines, Subham G Patel, Dipti B Upadhyay, Nirajkumar V Shah, Mehul P Parmar, Paras J Patel, Apoorva Malik, Rakesh K Sharma, Hitendra M Patel, RSC Sustainability,2024, 2, 1128-1141. DOI: 10.1039/D4SU00024B

 

50 A green bio-organic catalyst (taurine) promoted one-pot synthesis of (R/S)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches, Mehul P Parmar, Disha P Vala, Savan S Bhalodiya, Dipti B Upadhyay, Chirag D Patel, Subham G Patel, Srinivasa R Gandholi, Althaf H Shaik, Amy Dunne Miller, Joaquina Nogales, Sourav Banerjee, José M Padrón, Nasser Amri, Nagesh Kumar Kandukuri, Hitendra M Patel, RSC Advances, 2024, 14(13), 9300-9313. DOI: 10.1039/D4RA01391C

49 Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4(2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study, Bhalodiya, Savan S.; Parmar, Mehul P.; Upadhyay, Dipti B.; Patel, Chirag D.; Vala, Disha P.; Rajani, Dhanji; Patel, Hitendra M. Results in Chemistry,  2024, 7, 101304, DOI: 10.1016/J.RECHEM.2023.101304

48 Deep eutectic mixture (DEM)-assisted multicomponent synthesis of heterocycles, Divyang M. Patel, Hitendra M. Patel, Multicomponent Synthesis: Bioactive Heterocycles, 2024, De Gruyter, Volume 5, 399-409. DOI: 10.1515/9783110985313-011

47 Insights into microwave assisted synthesis of spiro-chromeno [2, 3-d] pyrimidines using PEG-OSO3H catalyst: DFT study and their antiproliferative activity, Subham G Patel, Paras J Patel, Dipti B Upadhyay, AdriánPuerta, Apoorva Malik, Nagesh K Kandukuri, Rakesh K Sharma, José M Padrón, Hitendra M Patel, Journal of Molecular Structure, 2024, 1292, 136174. DOI: 10.1016/j.molstruc.2023.136174

46 Catalyst-free synthesis of imidazo [5, 1-b] quinazolines and their antimicrobial activity, Paras J. Patel; Ruturajsinh M. Vala; Subham G. Patel; Dipti B. Upadhyay; Dhanji P. Rajani; Fouad Damiri; Mohammed Berrada; Hitendra M. Patel, Journal of Molecular Structure , 2022, 1285, 135467.

DOI: 10.1016/j.molstruc.2023.135467

 

45 Recent developments in the Hantzsch synthesis of dihydropyridines, RM Vala, HM Patel, Advances in Heterocyclic Chemistry ,2023, 141, 179-208.  DOI: 10.1016/bs.aihch.2023.04.001

44 Polysaccharide-based nanogels for biomedical applications: A comprehensive review, Fouad Damiri, Satish Rojekar, YahyaBachra, Rajender S Varma, SwethaAndra, SatheeshkumarBalu, Chandrakantsing VijaysingPardeshi, Paras J Patel, Hitendra M Patel, Ana CláudiaPaiva-Santos, Mohammed Berrada, Mónica C García, Journal of Drug Delivery Science and Technology,84,104447.

DOI: 10.1016/j.jddst.2023.104447

43 Water mediated TBAB catalyzed synthesis of spiro-indoline-pyrano [3, 2-c] quinolines as α-amylase inhibitor and in silico studies, DB Upadhyay, RM Vala, SG Patel, PJ Patel, C Chi, HM Patel, Journal of Molecular Structure ,2023, 1273, 134305.  DOI: 10.1016/j.molstruc.2022.134305

42 Importance of Hybrid Catalysts toward the Synthesis of 5 H-Pyrano [2, 3-d] pyrimidine-2-ones/2, 4-diones (Thiones), MP Parmar, RM Vala, HM Patel, ACS Omega , 2023, 8 (2), 1759−1816.

DOI: 10.1021/acsomega.2c05349

41 An efficient, catalyst-free and aqueous ethanol-mediated synthesis of 5-((2-aminothiazol-5-yl)(phenyl) methyl)-6-hydroxypyrimidine-2, 4 (1 H, 3 H)-dione derivatives and their antioxidant activity, PJ Patel, SG Patel, DB Upadhyay, L Ravi, A Dhanasekaran, HM Patel, RSC advances ,2023, 13 (35), 24466-24473.

DOI: 10.1039/D3RA03998F

40 Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity, RM Vala, V Tandon, LG Nicely, L Guo, Y Gu, S Banerjee, HM Patel, Annals of Medicine ,2022, 54 (1), 2548-2560. DOI: 10.1080/07853890.2022.2123559

39 Catalyst-Free, Room-Temperature Accessible Regioselective Synthesis of Spiroquinolines and Their Antioxidant Study, PJ Patel, DM Patel, RM Vala, SG Patel, DB Upadhyay, Y Pannerselvam, …, ACS omega 8 (1), 444−456. DOI: 10.1021/acsomega.2c05020

38 Catalytic Stereoselective Multicomponent Reactions for the Synthesis of Spiro Derivatives: Recent Progress, DM Patel, PJ Patel, HM Patel, European Journal of Organic Chemistry ,2022, (46), e202201119. DOI: 10.1002/ejoc.202201119

37 Microwave-assisted multicomponent synthesis of antiproliferative 2, 4-dimethoxy-tetrahydropyrimido [4, 5-b] quinolin-6 (7 H)-ones, Subham G Patel, Aday González-Bakker, Ruturajsinh M Vala, Paras J Patel, Adrián Puerta, Apoorva Malik, Rakesh K Sharma, José M Padrón, Hitendra M Patel, RSC Advances ,2022, 12 (47), 30404-30415. DOI: 10.1039/D2RA04669E

36 Versatile Synthetic Platform for 1,2,3-Triazole Chemistry, DP Vala, RM Vala, HM Patel, ACS Omega ,2022, 7 (42), 36945–36987.

DOI: 10.1021/acsomega.2c04883

35 Crystal structure, antibacterial and antifungal evaluation of 5-bromothiophene based 3, 4-dihydropyrimidin-2-(1 H)-(thi) ones, MG Sharma, RM Vala, DP Rajani, V Ramkumar, RL Gardas, S Banerjee, …, Phosphorus, Sulfur, and Silicon and the Related Elements ,2022, 198 (2), 145-153.

DOI: 10.1080/10426507.2022.2121397

 

34 Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones, Subham G. Patel, Ruturajsinh M. Vala, Paras J. Patel, Dipti B. Upadhyay, V. Ramkumar, Ramesh L. Gardas, Hitendra M. Patel*, RSC Advances ,2022, 12 (29), 18806-18820.

DOI: 10.1039/D2RA02694E

33 Syrbactin-class dual constitutive-and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo study , V Tandon, RM Vala, A Chen, RL Sah, HM Patel, MC Pirrung, S Banerjee, Biosci. Report ,2022, 44 (2), BSR20212721. DOI: 10.1042/BSR20212721

32 One-pot two-step catalytic synthesis of 6-amino-2-pyridone-3, 5-dicarbonitriles enabling anti-cancer bioactivity, Lynden G Nicely, Ruturajsinh M Vala, Dipti B Upadhyay, Joaquina Nogales, Celestine Chi, Sourav Banerjee, Hitendra M Patel, RSC Advances ,2019, 12 (37), 23889-23897.

DOI: 10.1039/D2RA03579K

31 Synthesis and in vitro study of antiproliferativebenzyloxydihydropyrimidinones, Ruturajsinh M Vala, Mayank G Sharma, Divyang M Patel, Adrián Puerta, José M Padrón, Venkatachalam Ramkumar, Ramesh L Gardas, Hitendra M. Patel*, Archiv der Pharmazie ,2021, 354 (6), 2000466.

DOI: 10.1002/ardp.202000466

30 Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-b]quinolinones, MG Sharma, RM Vala, HM Patel*, RSC Advances ,2020, 10 (58), 35499-35504.

DOI: 10.1039/D0RA06738E

29 A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro [pyrazolo [4, 3-f] quinoline]-8, 5′-pyrimidines and tetrahydro-pyrazolo [4, 3-f] pyrimido [4, 5-b] quinolines via selective multiple C–C bond formation under metal-free conditions, DM Patel, HJ Patel, JM Padrón, HM Patel*, RSC Advances ,2020, 10 (33), 19600-19609. DOI: 10.1039/D0RA02990D

28 One-Pot Assembly for Synthesis of 1,4-Dihydropyridine Scaffold and Their Biological Applications, Mayank G. Sharma, Juhee Pandya, Divyang M. Patel, Ruturajsinh M. Vala, V. Ramkumar, Raghunandankumar Subramanian, Vivek K. Gupta, Ramesh L. Gardas, Anuradha Dhanasekaran, Hitendra M. Patel*, Polycyclic Aromatic Compounds ,2019, 39 (5), 395-485. DOI: 10.1080/10406638.2019.1686401

27 Trimethylglycine-betaine-based-catalyst-promoted novel and ecocompatible pseudo-four-component reaction for regioselective synthesis of functionalized 6, 8-dihydro-1′ H, 5 H-spiro [[1, 3] dioxolo [4, 5-g] quinoline-7, 5′-pyrimidine]-2′, 4′, 6′(3′ H)-trione derivatives, DM Patel, HM Patel*, ACS Sustainable Chemistry & Engineering ,2019, 7 (22), 18667−18676. DOI: 10.1021/acssuschemeng.9b05184

26 Impact of an aryl bulky group on a one-pot reaction of aldehyde with malononitrile and N-substituted 2-cyanoacetamide, RM Vala, DM Patel, MG Sharma, HM Patel, RSC Advances , 2019, 9 (49), 28886-28893. DOI: 10.1039/C9RA05975J

25 A Practical Green Visit to the Functionalized [1, 2, 4] Triazolo [5, 1‐b] quinazolin‐8 (4H) one Scaffolds Using the Group‐Assisted Purification (GAP) Chemistry and Their Pharmacological Testing, DM Patel, RM Vala, MG Sharma, DP Rajani, HM Patel, ChemistrySelect , 2019, 4 (3), 1031-1041.

DOI: 10.1002/slct.201803605

24 Hydroxyl Alkyl Ammonium Ionic liquid assisted Green and One-pot regioselective access to Functionalized Pyrazolodihydropyridine core and their pharmacological evaluation, Divyang M Patel, Mayank G Sharma, Ruturajsinh M Vala, Irene Lagunes, Adrián Puerta, José M Padrón, Dhanji P Rajani, Hitendra M Patel*, Bioorganic chemistry ,2019, 86, 137-150. DOI: 10.1016/j.bioorg.2019.01.029

23 Synthesis, Molecular Docking and Biological Evaluation of Mannich Products Based on Thiophene Nucleus using Ionic Liquid, HM Patel*, DP Rajani, MG Sharma, HG Bhatt, Letters in Drug Design Discovery ,2019, 16 (2), 119-126(8). DOI: 10.2174/1570180815666180502123743

22 Anti‐Proliferative 1,4‐Dihydropyridine and Pyridine Derivatives Synthesized through a Catalyst‐Free, One‐Pot Multi‐Component Reaction, MG Sharma, RM Vala, DM Patel, I Lagunes, MX Fernandes, JM Padrón, …, ChemistrySelect ,2018, 3 (43), 12163–12168. DOI: 10.1002/slct.201802537

 

21 Synthesis, characterizations and microbial studies of novel mannich products using multicomponent reactions, HM Patel, Current Bioactive Compounds ,2018, 14 (3), 278-288. DOI: 10.2174/1573407213666170424164716

20 Green approach for synthesis of bioactive Hantzsch 1, 4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction, MG Sharma, DP Rajani, HM Patel*, Royal Society open science , 2017, 4(6), 170006. DOI: 10.1098/rsos.170006

19 Facile synthesis and biological evaluation of New Mannich products as potential antibacterial, antifungal and antituberculosis agents: molecular docking study, HM Patel*, KD Patel, HD Patel, Current Bioactive Compounds , 2017, 13 (1), 47-58. DOI: 10.2174/1573407212666160517145130

18 Synthesis of new mannich products bearing quinolinenucleous using reusable ionic liquid and antitubercular evaluation, HM Patel, Green and Sustainable Chemistry ,2015, 5 (04), 137.

DOI: 10.4236/GSC.2015.54017

17 Synthesis, characterization and dyeing assessment of novel acid azo dyes and mordent acid azo dyes based on 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid on wool and silk fabrics, HM Patel, BC Dixit, Journal of Saudi Chemical Society , 2014,  18 (5), 507-512.
16 Design, synthesis and biological evaluation of new Mannich products using ethyl ammonium nitrate as reusable ionic liquid., HM Patel, IOSR Journal of Applied Chemistry, 7 (8), 40-47.
15 Synthesis, structure investigation and dyeing assessment of novel bisazo disperse dyes derived from UV absorbing material, HM Patel, IOSR Journal of Applied Chemistry, 6, 51-55.
14 Solvent-free synthesis of mannich products catalyzed by ethyl ammonium Nitrate as reusable ionic liquid and there in vitro microbial studies., HM Patel, International Journal of Recent Scientific Research, 2014,  5 (10), 1799-1805.
13 Synthesis, characterization and dyeing assessment of novel bisazo-acid dyes derived from 2-hydroxy-4-methoxybenzophenone-5-sulphonic acid, HM Patel, Int. J. Sci. Engi. Res, 2014, 5 (1), 2213.
12 Synthesis, characterization and dyeing behaviour of heterocyclic acid and mordent dyes on wool and silk fabrics, HM Patel, Procedia Engineering, 2013, 51, 363-370.
11 Synthesis, characterization and applications of some novel mordent and heterocyclic disperse dyes on polyester and wool fibers, HM Patel, Orbital: The Electronic Journal of Chemistry, 2012, 4 (3), 159-170.
10 Synthesis, antimicrobial activity and absorption studies of some novel heterocyclic dyes based on 4-hexylbenzene-1, 3-diol, HM Patel, European Journal of Chemistry, 2012, 3 (1), 44-50.
9 Synthesis, characterization and dyeing behavior of heterocyclic acid dyes and mordent acid dyes on wool and silk fabrics, HM Patel, Journal of the Serbian Chemical Society,2012,  77 (11), 1551-1560.
8 Material applications of novel heterocyclic disperse and mordent dyes based on 2-butyl-3-(4-hydroxybenzoyl) benzofuran, HM Patel, Advances in Applied Science Research, 2012, 3, 235-241.
7 Dyeing assessment of some novel mordent and heterocyclic disperse dyes based on dihydrobenzofuran derivatives on to polyester and wool fibers, HM Patel, Der ChemicaSinica, 2012, 3 (1), 175-181.
6 Synthesis, characterization and printing application of solvent dyes based on 2-hydroxy-4-n-octyloxybenzophenone, BC Dixit, HM Patel, E-Journal of Chemistry, 8 (2), 615-620.
5 Synthesis, characterization and application of some novel mordent and heterocyclic disperse dyes based on 2-Butyl-3-(4-hydroxybenzoyl)benzofuran, HM Patel, Der ChemicaSinica , 2011, 2 (6), 89-96.
4 Material Applications of Novel Disperse and Mordent Azo Dyes Based on 2-Hydroxy-4-methoxybenzophenone, BC Dixit, HM Patel, Asian Journal of Chemistry, 2010, 22 (2), 921.
3 Synthesis, characterization and dyeing assessment of novel acid azo dyes and mordent acid azo dyes based on 2-hydroxy-4-methoxybenzophenone on wool and silk fabrics, BC Dixit, HM Patel, RB Dixit, DJ Desai, Journal of the Serbian Chemical Society, 2010,  75 (5), 605-614.
2 Studies on dyeing performance of novel acid azo dyes and mordent acid azo dyes based on 2, 4-dihydroxybenzophenone, BC Dixit, HM Patel, DJ Desai, RB Dixit, E-Journal of Chemistry, 2009,  6 (2), 315-322.
1 Synthesis and application of new mordent and disperse azo dyes based on 2,4-dihydroxybenzophenone

BC Dixit, HM Patel, DJ Desai, Journal of the Serbian Chemical Society, 2007,  72 (2), 119-127.